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Recombinant Human CDCP1

Recombinant Human CDCP1

庫存單位: 41901

★ Download Datasheet PDF ★

 

 

Type:

Recombinant

Cat. No.:

41901

Tag:

His

Size:

0.1 mg

Source:

CHO

Purity:

>95%

Endotoxin:

<5 EU/mg  

Species:

Human

  • INTRODUCTION TO THE MOLECULE

    CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. CDCP1 is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD).

    The phosphorylation of CDCP1 is seen in many cancers, it is a putative stem cell marker, and is reported as a key regulator of EGF/EGFR-induced cell migration. It also interacts with cell-cell adhesion glycoproteins including CDH3/P-cadherin, CDH2/N-cadherin, membrane proteins including, SDC1/syndecan-1, SDC4/syndecan-4, and integral membrane serine protease ST14/MT-SP1. Its phosphorylation may also play a role in the regulation of anchorage versus migration and proliferation versus differentiation.

  • DESCRIPTION

    A DNA sequence encoding the human CDCP1 (Met1-Ser367) was expressed with a polyhistidine tag at the C-terminus (Uniprot No. Q9H5V8-3). Its predicted molecular mass of 39.1 kDa. The concentration of protein was determined by BCA.

  • FORMULATION

    Lyophilized from sterile PBS, pH 7.4. 

  • RECONSTITUTION

    For reconstitution, add 100 μl of deionized water, mix gently and incubate the reconstituted product for 10 minutes at room temperature prior to use.

  • STORAGE

    Lyophilized protein can be stored at 2℃ to 8℃ for short-term, and at -20℃ to -80℃ for long term store. Reconstituted protein should be kept at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • QUALITY CONTROL TEST

    BCA to determine concentration of the protein.

    SDS PAGE to determine purity of the protein.

$324.00價格

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